USF: Novel Molecular Insights into Classical and Alternative Activation States of Microglia

Researchers at the University of South Florida (Department of Cell Biology, Microbiology, and Molecular Biology) used ScienCell’s mouse microglia in their research on the molecular mechanisms behind classical and alternative microglial activation. Through this study, they found a group of proteins differentially expressed in the classical M1, pro-inflammatory state and M2 (M2a, M2b, M2c) alternative activation. The data revealed new insights into the similarities and differences between the various states. Additionally, the proteomic data revealed a novel activation marker DAB2, which was notably different between the various states.